Jornal de Proteômica e Bioinformática
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Bioinformatic Analysis of Alzheimer?s Disease and Type2 Diabetes Mellitus: A Bioinformatic Approach

Allam Appa Rao, Siva Prasad Akula, Hanuman Thota, Srinubabu Gedela

We evaluated the role of several proteins that are likely to be involved in alzheimers disease (AD) and type 2 diabetes mellitus (T2DM). By employing multiple sequence alignment using Clustalw tool, we have constructed a phylogenetic tree based on the functional protein sequences extracted form NCBI. The phylogram was constructed using neighbor joining algorithm. Our bioinformatic analysis reported that the two proteins such as AChE and BChE are playing major role in both the diseases out of ten common proteins between these two diseases. Our in silico study may pave way for new therapeutic interventions/biomarker identification in alzimers disease associated diabetes mellitus.