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Difference Expression of m6A Regulators in Breast Cancer and its Relationship with Immune Response

Muhairemu Tuersuntuoheti, Xiaofang Chen, Jianghua Ou, Lina Yi, Xuelaiti Paizula, Yongtao Li

Objective: RNA N6-methyl Adenosine (m6A) plays a key role in tumor development. However, its role in breast cancer has not been fully elucidated.

Methods: In this study, 23 m6A RNA regulatory factors were systematically analyzed from the TCGA database to analyze the relationship between m6A and breast cancer by bioinformatics. Then, we further detected the expression of m6A by immunohistochemical method, and analyzed the relationship between it and the prognosis of breast cancer.

Results: We found increased expression of 6 regulators in breast cancer patients. We further studied the effect of abnormal expression of CBLL1, YTHDC1, METTL14, HNRNPA2B1, RBMX, and HNRNPC on the survival time of breast cancer. In addition, we also found that the abnormality of the M6A regulatory factor is closely related to immune infiltration and genetic changes.

Conclusion: Our findings suggest that the expression of m6A regulators in breast cancer has important clinical diagnostic significance and that abnormal expression may be associated with poor clinical prognosis in BC. This helps to provide us with a new direction of targeted therapy for breast cancer.