Jornal de Oftalmologia Clínica e Experimental
Acesso livre
ISSN: 2155-9570
ISSN: 2155-9570
Burak Turgut, Murat Kaya, Sonay Coskun, Orhan Aydemir an Nurettin Deniz
Purpose: Fi assess ocular hemodynamic response to intravitreal pegaptanib inna patients wid age related macular degeneration (AMD).
Methods: Both eyes a twenty patients wid choroidal neovascular membrane a at least four MPS (Macular Photocoagulation Study) disc area inna one eye due to AMD did a undergo ocular hemodynamic evaluation. Blood flow velocities a both eyes dem did measure by Color Doppler Ultrasonography (CDU) before an at first, fourth weeks afta intravitreal pegaptanib injection an calculate di arterial resistivity indices. Di Wilcoxon-signed rank test did use fi statistical analysis.
Results: Inna di treated eyes, di mean PSV (Peak Systolic Velocity) a OA (Ophthalmic Artery) increase significantly to a value a 45.37 ± 17.92 at di first (p=0.007), den return to an insignifi cant value a 42.19 ± 14.35 at di fourth week (p>0.05). Di mean PSV a CRA (Central Retinal Artery) increase signifi cantly to a value a 21.59 ± 6.21 at di first week (p=0.12) an, den remain inna a significant value a 21.06 ± 4.95 at di fourth week (p=0.006) . Di mean EDV (End-Diastolic Velocity) a CRA increase significantly to a value a 6.07 ± 2.30 at di first week (p=0.001) an, den remain inna a significant value a 6.20 ± 2.24 at di fourth week (p= 0.001) . Di mean PSV a PCA (Posterior Ciliary Artery) increase significantly to a value a 30.66 ± 10.73 at di first week in comparison to di value a at di fourth week (p=0.038). However, deh neva have no significant difference wid value a 26.57 ± 5.91 at di fourth week (p>0.05), wen dem compare wid pretreatment measurement (27.60 ± 7.84). CDU measurements inna untreated eyes neva show no significant change afta an before di injection.
Conclusion: Resistivity indices a CRA, PCA an OA neva chienj afta intravitreal pegaptanib az an anti- VEGF agent inna patients wid AMD.