Jornal de Ciência e Pesquisa do Câncer
Acesso livre

Abstrato

Plasticity of Tumor Suppressor Functionality of p53 Includes Potential Carcinogenesis in Terms of Subsequent Progression of the Malignant Transformation Event

Agius LM

Provoking plasticity of response of p53 involves mutations of the p53 gene within the further contextual accumulation of p53 protein within the cell cytoplasm. Activation of wild-type p53 gene and protein includes various post-translational modifications including specific phosphorylation and mutability performance of the core DNA binding domain in particular. Rigorous characterization and re-characterization of the essential accumulation of mutant p53 within the cytoplasm is itself a characterized reformulation of the essential transformation step per se and includes the dynamics of DNA damage repair that indicates malignant transformation a strict attribute of the initial DNA damage as structural dynamics of subsequent progression of potential carcinogenesis.