Jornal de Proteômica e Bioinformática
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Proteomics Analysis for Therapeutic Options of Neurodegeneration: A Review

Magdah A Ganash

Neurodegenerative diseases appear to share numerous common multifactorial degenerative processes that contribute to neuronal death, leading to functional impairments. Therefore researchers hope to understand the mechanisms of Neurodegenerative diseases in order to improve their chances of developing new therapies and strategies that may benefit patients. The Proteomics analysis is one of the strategies that researchers are focusing on in order to tackle such diseases as only through these analyses protein modifications can be characterized and be the targets of drugs that are identified. This review explores the various aspects associated with the neurodegenerative diseases and the recent proteomics analyses that may benefit their treatment. This review also strives to point out the literature hypothesized that oxidative modifications, mitochondrial dysfunction, and impairment of protein degradation execute neuron death. Numerous evidences present in literature raise the possibility the possibility that mitochondria and oxidative stress play a crucial role in neurodegeneration, opening new perspectives for therapy.