Imunoterapia: acesso aberto
Acesso livre

Abstrato

T-cell Immunity in Children after Rotavirus Infection

Gabriel Kotak*

In children, cellular immunity against rotavirus is poorly known. The present state of knowledge about T-cell immunity to rotavirus in children is described in this. Rotavirus-specific T-cell immunity develops and broadens responsiveness in children as they get older.

T-cell responses are more temporary than antibody responses, although they can happen even when there are no measurable antibody responses. Rotavirus-induced T-cell immunity is primarily gut homing, involving Th1 and cytotoxic subsets that may be modulated by IL-10 Tregs.

In compared to other infectious pathogens and adults, however, rotavirus-specific T-cell responses in children are often modest in frequency in peripheral blood. The available research on the T-cell immune response in children is summarised here. Rotavirus-specific T-cell responses have protective correlations against infection or vaccination and the standardization of rotavirus-specific T-cells assays in children.