Técnicas Avançadas em Biologia e Medicina
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Three Indicators of Oxidative Stress in the Evaluation of Hyperthyroidism

Pengbo Yang1, Li Ying2,3, Hexin Li4, Xiaoxia Wang5, Xiaofan Jia5, Lihui Zou5, Qi Pan5*, Xiangyi Liu6*

Background: Oxidative stress is closely related to many diseases, especially autoimmune diseases. Many previous studies have shown that there is a close relationship between oxidative stress and the development of hyperthyroidism, but the oxidative stress indicators in patients with hyperthyroidism and the correlation between oxidative indicators and lipid metabolism remain controversial. The aim of this study was to investigate the levels of three oxidative stress indicators Diacron Reactive Oxygen Metabolites, Biological Antioxidant Potential and Superoxide Dismutase (DROM, BAP and SOD) in hyperthyroidism patients and healthy controls, and their relationship with the severity of hyperthyroidism and lipid metabolism.

Methods: 119 healthy individuals and 78 hyperthyroidism patients were included in this study. Automatic biochemical analyzer was used to detect three indicators of oxidative stress (BAP, SOD and DROM), three indicators of thyroid function (TSH, FT3 and FT4) and four indicators of lipid metabolism (TG, TC, LDL, HDL and fasting blood glucose) in patients with hyperthyroidism and healthy controls.

Results: The basic levels of BAP and SOD in peripheral blood were significantly lower in hyperthyroidism patients compared to healthy controls (P＜0.001), while the level of DROM was significantly higher in patients with hyperthyroidism compared with control subjects (P＜0.05). There was no significant correlation between the three oxidative stress indicators and metabolites of glucose and lipid. The level of DROM was negative correlated with TSH and positive correlated with FT3 and FT4.

Conclusion: Oxidative stress and antioxidant system play an important role in the pathogenesis of hyperthyroidism. In patients with hyperthyroidism, the level of oxidative stress products (DROM) was increased and the levels of antioxidant capacities (SOD and BAP) were decreased. BAP tend to be a better biomarker of antioxidant level in hyperthyroidism patients compared with SOD.