Jornal de Toxicologia Clínica
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Ventricular Fibrillation Caused by Mianserin Poisoning

Takeshi Kitamoto, Kouichi Hayakawa, Fukuki Saito and Yasushi Nakamori

Case: A 56-year-old man who revived after ventricular fibrillation was transferred to the emergency center at Kansai Medical University. The blood examination, computed tomography, and cardiac echocardiography at the time admission could not detect the cause of ventricular fibrillation. However, high-performance liquid chromatography revealed mianserin and aripiprazole in his serum. The concentration of mianserin (48.7 mg/L), especially, was found to be very high. Therefore, we believed that ingestion of a large amount of mianserin could have induced ventricular fibrillation.