Jornal de Imunologia Clínica e Celular
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A Brief Note on Humoral Immune

Marion Pepper

Many successful immunizations depend on humoral immune responses to guard against invading microorganisms. Animal models using experimental vaccination systems have greatly contributed to our understanding of how humoral immunity develops. While these studies have advanced the field by identifying many of the fundamental principles of B cell development and function, we are only now beginning to understand the intricacies of humoral immune responses generated by infection. The adaptive immune system's co-evolution with the pathogenic world has resulted in a wide range of B cell responses to infections, with both shared and distinct methods. We discuss the general mechanisms that control the development of humoral immune responses during infection in this review, as well as recent studies indicating the evolution of unique survival strategies used by either the host or the pathogen.