Jornal de Imunologia Clínica e Celular
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A Brief Note on Tissue-Resident Memory Cells

Georg Gasteiger

Tissue-resident memory T (TRM) cells provide as a first line of defense against infections that enter through barrier locations. TRM cells in the lungs protect against infections, although they decline faster than TRM cells in other tissues. Because there isn't a stable TRM population in the lung parenchyma, infections with pathogens like influenza and respiratory syncytial virus (RSV) can reoccur throughout life. Intranasal (IN) vaccination with a murine cytomegalovirus (MCMV) vector expressing the RSV M protein (MCMV-M) has been demonstrated to produce large numbers of CD8⁺ TRM cells that accumulate over time and mediate early viral clearance. We evaluated the inflationary CD8⁺ T cell population generated by MCMV-M vaccination with a traditional CD8⁺ T cell population and further findings. Vaccination with MCMV-M2 resulted in a fast diminishing population of M2-specific CD8⁺ TRM cells, similar to the M2-specific CD8⁺ TRM cell population evoked by RSV infection. MCMV-M and MCMV-M2 administration, in contrast to the natural immune dominance profile, did not suppress the M-specific CD8⁺ T cell response, implying that progressive expansion was driven by continuous antigen presentation, regardless of the competitive or regulatory effects of M2-specific CD8⁺ T cells.