Jornal de Ensaios Clínicos
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A Connection between Factors Causing Diseases and Diseases Frequencies: Its Application in Finding Disease Causes

Alan Olan*

In this work an author is building a theoretical model of a non-infectious disease, which shows that there is a connection between diseases frequencies and their causes. This connection allows to determine how many factors are causing a specific non-infectious disease if we know the disease rate in a population. The model shows that for a majority of non-infectious diseases there are at least two simultaneously acting factors which cause a disease and in many cases there are more factors simultaneously involved. This helps researchers to improve an understanding of specific disease causation and physiological mechanisms behind it and will lead to a research for additional, still missing causes to complete these mechanisms. This work determines a number of simultaneously acting factors causing diseases such as a breast cancer, Coronary Heart Disease (CHD), multiple sclerosis, etc. and explains so called French Paradox for CHD. The work also deduces a formula and a method of determining that a specific risk factor is the one which really causes a disease or it is not. Applying a method developed in this work the author shows how three different simultaneously acting causes of atrial fibrillation are determined using an existing research data. This method should allow medical researchers to determine if a found risk factor for a disease is really a cause of the disease or not and covers a significant gap in current understanding of risk factors nature and its connection to the physiological parameters of the human body.