Jornal de Hematologia e Doenças Tromboembólicas
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A Note on Hemostatis

Prasanna Kattekola*

Haemostasis is very important mechanism of our body as it prevents from hemorrhage. Without this mechanism the survival of person is not possible. This system in our body represents a very delicate balance between pro-coagulant, anticoagulant allied to a method of fibrinolysis. This system consists of 5 major components in our body i.e. platelets, coagulation factors, coagulation inhibitors, fibrinolysis and blood vessels. [1]. many problems can arise in this system so these problems can be cured by a variety of medicinal plants and mushrooms. This system is controlled by thromboxane synthase (TXS), which converts prostaglandin H2 into thromboxane A2, a potent vasoconstrictor and platelet aggregator. Plasminogen activator inhibitor type 1 (PAI-1) also plays a role in haemostasis by inhibition of fibrinolysis, which prevents failure of this process. Subsequently, neutrophils release free radicals to kill bacteria the inflammation phase and heme. The heme proteins also accumulate at the local site of the wound.