Jornal de Pesquisa em Dermatologia Clínica e Experimental
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A Single Center, Randomized, Double-Blind Study to Evaluate TransFORM Body Treatment with TriHex Technology in Combination with RF Microneedling to the Suprapatellar Region

Deanne Mraz Robinson, Alessia Giannini, Syed Minhaj Rahman, Michaela Bell*, Alan Widgerow

Background: TransFORM Body Treatment with TriHex Technology^® (TFB) is a topical body treatment that works in parallel with body fat reduction procedures and energy-based body skin tightening procedures to optimize results. This study aims to evaluate the efficacy of TFB when used post Radiofrequency (RF) microneedling to reduce knee skin laxity and crepey skin texture associated with aging.

Objectives: Assess the efficacy of TFB compared to a bland moisturizer used post RF microneedling treatment to the suprapatellar region in relation to improvement of skin laxity, wrinkling and elastin stimulation.

Methods: In this randomized, double-blind clinical study conducted over 16 weeks, eligible subjects underwent one RF microneedling procedure to the right and left suprapatellar region, with follow-up visits at 4, 8, 12 and 16 weeks post-treatment. Post procedure, the blinded products, were applied twice daily to the designated side, for the duration of the study. Assessments included blinded investigator and subject assessments, biopsies, standardized photography and roughness index measurements.

Results: 15 female subjects with a mean age of 52.4 years completed the study. Clinical grading measurement scores demonstrated improvement for all evaluated parameters when compared to baseline, with TFB showing statistically significant improvement in skin smoothness when compared to the bland moisturizer. Skin roughness index mirrored the improvement seen clinically and biopsies showed increased elastin generation in 5/5 slides on TFB side and 1/5 on the comparator side.

Conclusions: The use of TFB demonstrates a synergistic effect with RF microneedling related to skin smoothness and elastogenesis when used post RF microneedling of the suprapatellar. TFB appears to enhance healing and aesthetic outcomes and with ongoing use is likely to provide long term benefits.