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An Efficient Method for the Synthesis of Bis(indolyl)methane Catalyzed by Nickel (II) Iodide

Ramesh S, Saravanan D

A simple mild, efficient synthetic methodology developed for the preparation of Bis(indolyl)methanes catalyzed by NiI₂ in MDC medium at room temperature. Several substituted aldehydes with indoles under this reaction condition is elucidated. The features of this methodology are shorter reaction time, less equivalence of the reagent, clear reaction profile and simple work up procedures.