Jornal de Ciência e Pesquisa do Câncer
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An Overview on Key Events and Factors Involved in Tumorigenesis

Roshan Rosati*

Tumorigenesis, the process by which normal cells transform into cancerous cells, is a complex and multifaceted phenomenon that has researchers and medical professionals since numerous years. It is essential to understand how tumors develop in the fight against cancer, as it provides critical insights into its prevention, diagnosis, and treatment. At its core, tumorigenesis is affected by a series of genetic and epigenetic alterations that disrupt the delicate balance between cell proliferation and death, unleashing uncontrolled cell growth. These alterations can arise from various influencing factors, including genetic mutations, exposure to carcinogens, viral infections, chronic inflammation, and hereditary predispositions. Each factor contributes differently to the initiation and progression of cancer, making tumorigenesis a heterogeneous process.