Jornal de termodinâmica e catálise
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Abstrato

Antioxidant Status of Cement Dust-Exposed Albino Rats Treated with Aqueous Extract of Turmeric

Obijuru TN, Uzomba NI, Nnaoma IE

Exposure to cement dust facilitates the reactions in which free radicals are produced in different parts of the body. The components of cement such as silica and chromium pose danger to cellular components such as proteins, nucleic acid, DNA and membrane lipid. This study was grouped into normal control, positive control, negative control and cement exposed treated group. The turmeric extract was administered for 14 consecutive days. Each dose was administered daily, 3hours after 30 minutes of exposure to cement dust. Superoxide dismutase was determined by method of sun and sigma while lipid peroxidation by Nichans and Samuelson. The concentration level of the Superoxide Dismutase was significantly reduced in negative control compared with the normal while treatment with turmeric extract increased the concentration of the superoxide Dismutase at a non significant level (p<0.05). Lipid Peroxidation level of the untreated (negative control) significantly increased compared with the normal control, treatment with turmeric reduced the lipid peroxidation at non significant level when compared with the negative control (p<0.05). There was no significant change observed in the weight of the groups of rats. Cement dust exposure doesn’t affect weight. The result shows a decrease in superoxide dismutase and increase in lipid peroxidation during cement dust exposure. Turmeric root extract does not return the altered parameters to normal concentration[1-10].