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Aptamers from Biology to Find Solutions in Immunohematology

Sabry Abdallah Shoeib, Alaa Efat Abd Elhamid,Enas Sobhi Zahran,Ahmed Abd Elmottlep Elkalashy

Introduction: Aptamers are small single-stranded oligonucleotides (DNAs or RNAs) of low Mw that can form a specific 3d structure and can be produced by a sofesticated method known as Systematic Evolution of Ligands by EXponential enrichment (SELEX). aptamer technology has been used for medical and clinical purposes Due to their specific physical, chemical and biological properties.

Aim of the work: to study the aptamers from stuctural biology and its application in diagnosis and treatment modalities in different immuno-hematological disorders as aprospective solution.

Conclusions: We can safely conclude that aptamers are considered as a promising class of diagnostic and therapeutic agents.