Revista de Cuidados Farmacêuticos e Sistemas de Saúde
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Artesunate Induced Hepato-Toxicity and its Amelioration by Allium sativum in Swiss Albino Male Mice

Ketaki R Desai, Pragnesh B Patel, Juhika Pandit, Dhrupadsinh K Rajput and Hyacinth N Highland

The use of natural antioxidants as mitigating agents has become prevalent. Garlic (Allium sativum) is one such agent which has been proven to have antibacterial, antiseptic, antifungal, antiparasitic, anticoagulant and antitumor properties. The present investigation deals with the ameliorative effects of Allium sativum on the antimalarial drug induced hepato-toxicity. Artesunate is being used as an alternative anti-malarial drug against conventional drugs like chloroquine. Experimental animals were divided into six groups of six mice each. Group A served as the control group. Group B and Group C animals were given 150 mg/kg b.wt and 300 mg/kg b.wt of artesunate respectively while Group D mice were given 100 mg/kg b.wt of Allium sativum. Group E and F mice were given 150 mg/kg b.w of artesunate+100 mg/kg b.wt Allium sativum and 300 mg/kg b.wt of artesunate+100 mg/kg b.wt Allium sativum respectively. Results exhibited recovery and re-establishment of various altered indices as opposed to Artesunate treated groups. Thus, Allium sativum might be used as a potent mitigating agent against anti-malarial drug toxicity. However, further research is needed to completely elucidate the ameliorative efficacy of Allium sativum.