Jornal de Toxicologia Clínica
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Ascorbic Acid Mitigates the Sodium Metabisulphite Induced Neonatal Pathophysiology: Study Reveals in Rodents

Muhammad Aslam*

Sulphites like Sodium Metabisulphite are commonly used as preservatives in food items, beverages, cosmetics and pharmaceuticals. Data about the adverse effects of such chemicals is missing in regards to infants and children’s. The aim of current study was to evaluate the effect of a Sodium Metabisulphite on prepubertal rats as analogue model to human child. Thirty-two prepubertal rats (28-30 postnatal days) were divided into four groups (8/group). They received distilled water, Sodium Metabisulphite (75 mg/kg/day), vitamin C (20 mg/ kg/day) and sodium metabisulphite+vitamin C. All the animals received daily gavages for 4 weeks. Parameters included body weight gain, hematology, serum chemistry, oxidative stress markers and antioxidant level in serum. Mean body weight gain was markedly decreased. Complete blood count, liver function test (AST, ALT and ALP), kidney function test (creatinine and urea) oxidative stress biomarkers (TBARS and ROS) and antioxidant enzymes level (SOD, POD, CAT and GSH) showed significantly pathophysiological hallmarks caused by Sodium Metabisulphite and were ameliorated by the vitamin C. The present study has demonstrated adverse effect of food additives like Sodium Metabisulphite exposure at neonatal life can induce profound toxic effects in rodents.