Medicina de Emergência: Acesso Aberto
Acesso livre

Abstrato

Association between the Severity of Tramadol Toxicity and Some CYP2D6 Allelic Variants in Egyptian Tramadol Intoxicated Patients

Samah F Ibrahim, Mona M Ali, Ahmed S Gouda and Laila A Rashed

Cytochrome P450 gene polymorphism is involved in the metabolism of tramadol. We investigated the effect of CYP2D6 gene polymorphism on tramadol metabolism by studying CYP2D6*1, CYP2D6*DUP, CYP2D6*4, and CYP2D6*10. CYP2D6 genotyping was performed using the xTAG CYP2D6 Kit v3 which incorporates multiplex PCR (Luminex kit). Tramadol levels were assessed using enzyme immunoassay. Our Study was done on 100 Egyptian patients with acute tramadol intoxication and 100 healthy control subjects. The patients were admitted to NECTR center. CYP2D6*1 was the most presented allelic variant in both groups The CYP2D6*DUP is associated with severe intoxication. There was a significant association between CYP2D6 allelic variants and tramadol metabolites level. In conclusion, our data suggests that studying CYP2D6 allelic variants may help clinicians to predict the severity of tramadol intoxication and individualize the drug treatment.