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Bilateral Adrenal Primary Diffuse Large B-Cell Lymphoma not Accompanied by Adrenal Insufficiency: A Report of Two Cases

Zheng Lei, Wang Qi-fei, Jiang Tao, Li Quan-lin, Wang Ke-nan and Wu Guang-zhen

Primary adrenal lymphoma (PAL) is uncommon in clinical settings, which is considered a rare high grade malignant lymphoma with a poor prognosis, patients with bilateral mass are rarer, and patients with normal adrenal function are extremely rare. We present 2 cases of patients with bilateral adrenal primary diffuse large B-cell lymphoma (PA-DLBCL) whose adrenal functions were normal. 2 patients were treated with unilateral adrenalectomy and a combination of chemotherapy. We summarized cases, reviewed the literature and discussed important issues with regard to the pathology change, diagnosis, treatment and prognosis.