Jornal de Pesquisa em Dermatologia Clínica e Experimental
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Case Reports: Full Facial Rejuvenation with Definisse™ Fillers

Gabriel Siquier Dameto, Dennis Malvin Hernandez Malgapo

Background: Several known factors contribute to the visible signs of facial aging. Changes in dentition and bony architecture, facial fat loss, diminished dermal thickness, and loss of dermal and subcutaneous support structures may result in folds and hollows that age the face. Filling age-related deficits of the face with fillers, such as hyaluronic acid, restores a more youthful appearance without the need for invasive techniques. Objectives: Definisse™ fillers are stable and long-lasting owing to their higher G’ compared to other benchmarked fillers; this property allows for excellent projection with a small amount of product used in patients with moderate to severe signs of aging. This paper is the first report on the clinical effects of Definisse™ fillers. Methods: We present two cases demonstrating the safety and efficacy of combined full-face treatment using different Definisse™ fillers with different injection techniques and devices. Results: Both patients tolerated the procedure well and showed visible signs of appearance improvement. Conclusion: Definisse™ fillers represent a set of HA fillers that can be considered as an option for patients with moderate to severe signs of aging who wish to achieve a more youthful appearance.