Jornal de Oftalmologia Clínica e Experimental
Acesso livre

Abstrato

Changes inna BDNF an MAPK Signaling Pathways inna Experimental Glaucoma

Fabiani Carlotta, Elisa Cerri, Sara Ottino, Marco Sansò an Luciano Domenici

Glaucoma is currently recognized as a multifactorial, progressive, neurodegenerative disorder. It is characterized by di retinal ganglion cells (RGCs) loss of axons as well as optic nerve atrophy, progressive degeneration of RGCs til cell death. Inna dis work, wi use DBA/2J mice as a model a spontaneous glaucoma an wi investigate di involvement a BDNF an Mitogen-Activated Protein Kinases (MAPK) pathways inna correlation wid IOP elevation an progression a neurodegenerative processes inna di retina a DBA/2J rat dem. In particular, we did perform western blot analysis fi study retinal levels a di BDNF an it receptor, TrkB, an fi beta andastan possible modulation a p38 MAPK an ERK1/2 activation at different stages a retinal degeneration inna DBA/2J mice. Wi did show seh BDNF staat fi decrease already at an early stage inna correspondence to IOP elevation (7 months of age). MAPKs, in particular p38 MAPK an ERK1/2, did appear maximally affected at more advanced stages a neurodegeneration (10-12 an 18 months a age) characterized by RGC degeneration an death, optic nerve atrophy. So, BDNF signaling an MAPKs dem differentially activate at different stages a retinal degeneration inna DBA/2J mice, a murine model a glaucoma.