Jornal de Cuidados com a Saúde da Mulher
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Characterization of polycystic ovarian syndrome (PCOS) in serum, follicular fluid, and cumulus cells

Lynn Greenbault*

PCOS is a metabolic syndrome in which steroidogenesis, folliculogenesis, and cellular adhesion all play important roles in prognosis. These pathways are controlled and regulated by microRNAs, which are small non-coding RNAs (miRs). Several miRs have differential expression in PCOS compared to healthy women, implying that miRs play important roles in PCOS pathophysiology. However, the role of miRs in various phenotypes of PCOS remains unknown. The purpose of this study was to assess the diagnostic potential of miR-212-3p, miR-490-5p, miR-647, and miR-4643 in different subtypes of PCOS. In general, PCOS significantly increased the expression of miR-212-3p, miR-490-5p, and miR-4643 in FF and CCs when compared to controls. Although these miRs tend to increase in PCOS patients' serum 1, the differences were insignificant.