Jornal de Oftalmologia Clínica e Experimental
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Cryoablation-Induced Anti-Cancer Immune Reaction

Shinji Osada, Hisashi Imai, Yoshiyuki Sasaki and Kazuhiro Yoshida

Ablative techniques have been developed against advanced liver cancer in cases where surgical resection is impossible. Among the ablation procedures used, thermal ablation therapy is widely applied, and the safety and efficacy of this technique have been well characterized to control local progression of cancer. However the principle of cryosurgery is not only to control local recurrence, but also to stimulate the immune system into initiating an anti-tumor response. In recent years, we have used a liquid nitrogen-based cryogenic procedure and developed a treatment method for patients with unresectable liver tumors. Following this, repeated treatment was demonstrated to induce anticancer immune reaction-related factors. In the present study, a novel strategy of a cryoablation-induced anti-cancer immune reaction will be introduced.