Design de Medicamentos: Acesso Aberto
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Development of Multi Unit Pellet System (MUPS) in Capsule

Y. Sai Sruthi, M. Sunitha Reddy

Capsules are the single unit dosage forms that are used for the immediate release of the drug into the systemic circulation. Now a day’s capsules are modified to deliver the drug as controlled, modified, delayed release dosage form. Most commonly used controlled release form of capsules is filled by mini tablets, mini capsules, pellets, powders, liquids and semi solids. There are two types of capsules they are soft and hard gelatin capsules, soft are used for the filling semisolids and liquids and hard are used for the filling pellets, tablets, capsules and powders. MUPS (Multi-Unit Pellet System) are the multi particulate pellet formulation that can be administered as tablet or capsules these after administration get disintegrated and covert into their sub unit so they show the combine advantage of tablets and capsules. MUPS are prepared by the pelletization technique that is formation of agglomerates among particles that convert the fine particles into the free flowing spherical or semi spherical units. The size of pellets ranges from the 0.5 to 1.5 mm. The most commonly used pelletization techniques are balling, globulation, drug layering and compaction. Fluid bed processor is the most preferred pelletization technique for the MUPS. These are mostly used for the controlled delivery of the drug and for increase the bio availability and to decrease the local irritation of some drug.