Jornal de Alcoolismo e Dependência de Drogas
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Editorial note on alcohol drinking causes cognitive disorders

Lucy Mutuli

Adolescent alcohol binge drinking constitutes a serious vulnerability factor to develop cognitive disorders. However, the pathways of treatment or prevention against this susceptibility remain less explored. Argon oil (AO), commonly utilized in traditional Moroccan medicines, is rich in oleic and linoleic acids, polyphenols, sterols, and tocopherols. This composition gives it numerous beneficial pharmacological effects of psychological state . within the current study, we evaluated the short-term and long-term AO effects on; memory and learning deficits induced by adolescent binge-like ethanol intoxication; the oxidative status of the hippocampus and therefore the prefrontal cortex (PFC) in Wister rats. To model binge-like ethanol intoxication, every 2 days, rats received an ethanol injection (3.0 g/kg) for two consecutive days across 14 days either from postnatal day 30 (PND30) to 43 (early adolescence). Also, the catalase and SOD (SOD) activities, the lipid peroxidation and nitrite concentrations were measured using spectrophotometric methods. AO pretreatment increased the performance of memory , recognition memory and spatial memory in rats previously intoxicated by ethanol, no matter the age and sex of the animals.