Jornal de Osteoporose e Atividade Física
Acesso livre

Abstrato

Efficacy and Security of Anti-Sclerostin Antibodies within the Treatment of Osteoporosis

Adriana Oliveira

Osteoporosis could be an inveterate infection with an expanding predominance. Anti-sclerostin antibodies are being explored for the treatment of osteoporosis. This point of this precise audit and meta-analysis is to assess the viability and security of antis-sclerostin antibodies compared to fake treatment and ordinary treatments (alendronate and teriparatide) within the treatment of osteoporosis. Randomized controlled trials were looked from PubMed, EMBASE and Cochrane Central Enroll of Controlled Trails (CENTRAL) from their initiation up to June 2021 by utilizing Restorative Subject Headings terms “anti-sclerostin antibody”, “romosozumab”, “blosozumab”, “AMG 785”, “LY2541546”, and “osteoporosis”. Two examiners freely screened qualified thinks about, evaluated the hazard of predisposition and extricated the information from each think about. The I2 file was utilized to survey heterogeneity. Meta-analysis was conducted utilizing the Survey Supervisor Program (RevMan, Adaptation 5.4). The Review approach was utilized to rate the quality of prove for all the pooled results.