Jornal de Doenças Infecciosas e Medicina Preventiva
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ESBL-Producing E.coli and Klebsiella among Patients Treated at Minia University Hospitals

Ahmed A.Fadil Saedii, Ahmed R. Abdelraheim, Ahmed A.Abdel-Aziz and Salwa H. Swelam

Background: Extended spectrum beta-lactamases (ESBLs) are group of bacteria producing enzymes which can destroy one or more antibiotics. ESBL producing organisms are resistant to many types of antibiotics which would normally be used to treat such infections thus considered as multi-drug resistant (MDR). The emergence and spread of ESBL is a public health threat as it is usually associated with an increase of morbidity, mortality and healthcare costs. Aim of the work: Detecting the prevalence of nosocomial infections caused by ESBL-producing E.coli and Klebsiella species among patients treated at Minia University Hospitals.

Methods: Eighty-five isolates from nosocomial infections at Minia university hospital due to E.coli and Klebsiella species were screened for ESBL production phenotypically and by PCR Results: Out of 85 isolates causing nosocomial infections at Minia university hospitals during the period of April 2014 - April 2015, the prevalence of E.coli was 52 isolates (61.1%) while Klebsiella spp. was 33 isolates (38.9%). The prevalence of ESBL among all the isolates of E.coli and Klebsiella species was 32.8% (28/85); with a prevalence of 16.4% among E.coli and 16.4% among Klebsiella spp. Isolates.

Conclusions: The prevalence of ESBL in Minia University Hospitals was 32.8% among the nosocomial infections. The predictors for the nosocomial acquired ESBL-EK infections were; old age, long hospital stay, mechanical ventilation, diabetes mellitus and prior antibiotics intake.