Jornal de Oftalmologia Clínica e Experimental
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Evaluation of Microcirculation Parameters in Optical Coherence Tomography Angiography in Retinal Vein Occlusion Before and After Aflibercept Treatment: A Review

Dorota Spiewak, Lukasz Drzyzga, Mariola Dorecka, Dorota Wygledowska-promienska

After diabetic retinopathy, Retinal Vein Occlusion (RVO) is the second most common disease of the retinal vessels that reduces visual acuity. The degree of retinal damage and visual acuity reduction correlate positively with the size and location of the obstructed venous vessel supplying the retinal area and with the possibility of collateral circulation formation. Optical Coherence Tomography Angiography (OCT-A) is a modern, non-invasive method of assessing haemodynamics in the retinal and choroidal vessels. OCT-A is helpful in diagnosing RVO and assessing treatment effects. In this review, we present the changes in OCT-A examination of RVO patients before and after treatment with intravitreal aflibercept injections. Anti-Vascular Endothelial Growth Factor (Anti-VEGF) treatment in the RVO patients reduces the Non-Perfusion Area (NPA), improves retinal blood flow, reduces retinal ischemia and cystoid macular oedema and improves visual acuity.