Jornal de Pesquisa em Dermatologia Clínica e Experimental
Acesso livre

Abstrato

Exosomes and Stem Cell Therapy Advancements Accelerated and Improved Burn Wound Healing

Maisa Ribeiro*

Burn injuries pose a significant public health challenge, particularly in conflict-affected regions, leading to
debilitating functional and cosmetic impairments. Current treatment options include debridement, skin grafts, and
silicone therapy, but they have limitations in addressing the complex nature of burn wounds. Stem cell therapy,
especially using Mesenchymal Stem Cells (MSCs), offers a potential avenue for enhancing natural skin regeneration
processes. MSC-based therapy has demonstrated efficacy in promoting wound healing by modulating inflammation,
promoting angiogenesis, and facilitating tissue regeneration. Various stem cell sources, such as Adipose-Derived Stem
Cells (ADSCs), Bone Marrow-Derived MSCs (BM-MSCs), and umbilical cord blood MSCs, have been explored for
their therapeutic potential in burn wound management. Despite the potential outcomes, challenges such as protocol
standardization, long-term follow-up, and patient selection optimization persist. Nonetheless, stem cell therapy holds
significant potential for revolutionizing burn injury treatment and improving patient outcomes. Further research is
needed to elucidate the underlying mechanisms and optimize treatment strategies for effective translation into
clinical practice.