Imunoterapia: acesso aberto
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Exploring the Immunomodulatory Effects of Vitamin D3 in Sars-Cov2 Management

Michele Malaguarnera, Lucia Malaguarnera*

Severe SARS-CoV2, the latest pandemic infectious diseases, is a serious threat to human health. SARS-CoV2 infection causes immune activation and systemic hyper-inflammation which can lead to respiratory distress syndrome (ARDS). ARDS victims are linked to sustained IL-6 and IL-1 increase. Macrophage activation associated with the “cytokine storm” promote the dysregulation of the innate immunity. So far without vaccines or specific therapy, all efforts to design drugs or clinical trials are deserving. Vitamin D and its receptor vitamin D receptor (VDR) exert an important role in infections for their remarkable impact on both innate and adaptive immune responses and on the suppression of inflammatory process. The protective effects of vitamin D supplementation have been proved by several observational studies and by meta-analysis of clinical trials for prevention of viral acute respiratory infection. In this review we compare the mechanisms of host immune response to SARS-CoV2 infection and the immunomodulatory actions that vitamin D exert in order to explore the preventive effect of vitamin D supplementation on SARS-CoV2 viral infection.