Jornal de Desenvolvimento de Drogas
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Abstrato

Formulation Studies on Hibiscus Sabdariffa (HS) Aqueous Extract

Y.J. Oyeniyi1*, F.B.O. Mojiminiyi2

Background: Hibiscus sabdariffa L. family Malvaceae is a perennial herbaceous medicinal shrub widely cultivated for its proven anti-hypertensive property

Objectives: The focus of this investigation is to formulate the aqueous extract of HS as oral tablets for accurate dosing and to ease the administration of the aqueous extract.

Method: Five formulations of HS granules were prepared by wet granulation technique and thereafter the flow characteristics of the granules were assessed through, angle of repose, Hausner’s ratio, density measurements, moisture content and compressibility index determinations. Heckel and Kawakita analyses were however employed to study HS granules compactability, while the United State Pharmacopeia 2012 (USP) quality control tests were used to investigate the tabletting properties.

Result: There were significant differences (p = 0.05) in the values obtained for the granules flow, compaction and tabletting properties. The ranking order was the same for the angle of repose and the Hausner’s ratio; HS2 = HS3 = HS4 = HS5 = HS1, implying HS2 having the best desirable flow characteristics. All the formulations underwent significant volume reduction under applied pressure, of which the PY and PK values ranked HS1 = HS2 = HS4 = HS5 = HS3 and HS4 = HS5 = HS2 = HS3 = HS1 respectively. All formulations except HS1 passed the quality assessment tests. HS1 even though had the fastest onset of plastic deformation; it however had the least quantitative plasticity and this may be responsible for its poor friability.

Conclusion: All HS Formulations except HS1 investigated had excellent tabletting properties that fell within the specifications of the United State Pharmacopeia. The high friability of HS1 may not be unconnected to its lack of binding agent and low plasticity even though it onset of plastic deformation was the fastest.