Journal of Glycomics & Lipidômica
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Abstrato

Functional proteomics for biomarker and drug discovery

Manuel Fuentes

In post-genome era having sequence the human genome, one of the most important pursuits is to understand the function of gene-expressed proteins. The overwhelming size and complexity of human proteome requires very high-throughput techniques for rapid analysis. Despite significant advancements in molecular biology and genetic tools, this demand has not been satisfied and only a small fraction of the proteome has been understood at the biochemical level. Systems Biology and Proteomics strive to create detailed predictive models for molecular pathways based upon quantitative behavior of proteins. Understanding these dynamics networks provides clues into the consequence of aberrant interactions and why they lead to diseases such as cancer. Historically, methods capable of collecting quantitative data on biochemical interactions could only be used for one or a few proteins at the time. Protein microarrays allow hundreds to thousands of proteins to be analyzed simultaneously, providing an attractive option for high-throughput studies such as protein-protein interaction, differential protein profiles. Here, a novel approach based on combination of nanotechnology and proteomics tools for biomarker and drug discovery useful for earlier diagnosis and personalized medicine will be presented.