Jornal de Pesquisa de Tumores
Acesso livre

Abstrato

Fusion molecules as a new concept to take chemotherapy to the next level

Thomas Mehrling

Past attempts to improve treatment efficacy, by inventing various combinations of cytotoxic agents, have provided disappointing results. Patients, mostly treated in large cooperative trials, experienced little benefit from intensification of dose and schedule but instead suffered from frequent and severe adverse reactions. Classical chemotherapy now finds itself at a crossroad. In some cancers, treatment is increasingly reliant on just targeted therapies; whereas in others the demand for a less toxic combination of chemotherapy and targeted therapies creates the need for different drugs or ‘smarter’ ways to deliver chemotherapy to the tumor. As demand drives innovation chemotherapy is about to evolve, more effectively targeting tumor cells while reducing damage to healthy tissues. Two important trends are emerging: The development of antibodydrug conjugates (ADCs) and the exploitation of synergies of targeted and cytotoxic therapy through fusion molecules. Fusion molecules combine an established chemotherapy principle with a synergistic targeted mode of action in one molecule. By exerting their dual action simultaneously, fusion molecules may overcome the difficulties of combining single agents with different pharmacokinetics and other pharmacological factors. One fusion molecule, currently in development, combines the strong alkylating activity of bendamustine with the histone-deacetylase (HDAC) inhibitor vorinostat. The synergies of HDACinhibition and DNA-damaging agents, such as alkylators, provided the rationale for the synthesis of the first-in-class fusion molecule bendamustine- vorinostat. It is anticipated that this fusion molecule may have strong activity in various hematological malignancies and solid tumors.Chemotherapy is a medication treatment that utilizes incredible synthetics to murder quickly developing cells in your body. Chemotherapy is regularly used to treat malignancy, since disease cells develop and increase substantially more rapidly than most cells in the body. A wide range of chemotherapy drugs are accessible. Chemotherapy medications can be utilized alone or in blend to treat a wide assortment of malignancies. In spite of the fact that chemotherapy is a compelling method to treat numerous kinds of malignancy, chemotherapy treatment likewise conveys a danger of reactions. Some chemotherapy symptoms are mellow and treatable, while others can cause genuine entanglements. The objectives of chemotherapy rely upon the kind of malignant growth and how far it has spread. Now and then, the objective of treatment is to dispose of all the disease and shield it from returning. On the off chance that this is preposterous, you may get chemotherapy to postpone or slow malignancy development. Deferring or easing back malignant growth development with chemotherapy additionally oversees manifestations brought about by the disease. Chemotherapy given with the objective of deferring disease development is at times called palliative chemotherapy. There are numerous medications accessible to treat malignant growth. A specialist who spends significant time in rewarding malignancy with drug, called a clinical oncologist, will recommend your chemotherapy. You may get a mix of medications, since this occasionally works better than just 1 drug.Chemotherapy is frequently given for a particular time, for example, a half year or a year. Or on the other hand you may get chemotherapy for whatever length of time that it works. Symptoms from numerous medications are too serious to even consider giving treatment consistently. Specialists as a rule give these medications with breaks, so you have the opportunity to rest and recuperate before the following treatment. This lets your solid cells recuperate. For instance, you may get a portion of chemotherapy on the principal day and afterward have 3 weeks of recuperation time before rehashing the treatment. Every 3-week time span is known as a treatment cycle. A few cycles make up a course of chemotherapy. A course for the most part endures 3 months or more. A few tumors are treated with less recuperation time between cycles. This is known as a portion thick timetable. It can make chemotherapy more powerful against certain malignant growths. Yet, it additionally expands the danger of reactions. Talk with your social insurance group about the best calendar for you.