Jornal de Pesquisa em Dermatologia Clínica e Experimental

Jornal de Pesquisa em Dermatologia Clínica e Experimental
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ISSN: 2155-9554

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Gender Matter in Isotretinoin Therapy for Acne Vulgaris? A Retrospective Study

Nevena Skroza, Riccardo Pampena, Ersilia Tolino, Sara Zuber, Giorgio La Viola, Nicoletta Bernardini, Ilaria Proietti, Veronica Balduzzi, Fowzieh Rasras, Concetta Potenza

Introduction: Gender differences have been recently highlighted for several aspects of acne vulgaris such as epidemiology, pathogenesis, clinical course, quality of life and treatment outcome. In particular a shorter but more severe clinical course has been reported in males than in females; nevertheless, usually men have their quality of life less affected.

Aim: To determine if the response and the adverse events to 1 cycle of oral isotretinoin therapy can be influenced by gender.

Methods: A retrospective study was conducted on consecutive patients affected by acne vulgaris and treated with oral isotretinoin. Global acne grading system (GAGS), acne-related quality of life (AQoL) and isotretinoin-related adverse events were considered as outcome measures and were evaluated before (T0), every month during administration and 4 weeks after the withdrawal (T1) of oral isotretinoin therapy. Mann-Whitney U test and Wilcoxon signed-rank test were used for quantitative parameters and Fisher exact test for qualitative ones.

Results: Forty-nine acneic patients were retrospectively selected (33 males 67.3% and 16 females -32.7%; median age: 19 years). Patients had received a median dosage of isotretinoin of 0.4 mg/kg/die for a median period of 5 months; no differences in outcome measures among genders were reported.

Limitations: The study is retrospective and the sample is small and not homogenously distributed among genders, as males are double in number than females.

Conclusions: In our study population gender didn't influence neither the clinical and the quality of life outcome measures nor the occurrence of adverse events to oral isotretinoin therapy for acne.

Isenção de responsabilidade: Este resumo foi traduzido com recurso a ferramentas de inteligência artificial e ainda não foi revisto ou verificado.
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