Jornal de Ciência e Terapia Celular
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GRK4, A Potential Link between Hypertension and Breast Cancer

Wei Yue*, John J. Gildea, Peng Xu, Robin A. Felder

Hypertension and breast cancer are two common diseases occurring in women. Clinical studies have shown increased breast cancer incidence in hypertensive women. Several lines of evidence demonstrate that G proteincoupled Receptor Kinase 4 (GRK4) could be a common risk factor for hypertension and breast cancer. This article reviews our current understanding of molecular mechanisms of GRK4 in hypertension and breast cancer.