ISSN: 2456-3102
Ilona Hromadnikova, Katerina Kotlabova, Lucie Hympanova and Ladislav Krofta
Aim: To demonstrate that pregnancy complications are associated with alterations in cardiovascular and cerebrovascular microRNA expression in maternal circulation. We focused on microRNAs playing a role in pathogenesis of dyslipidemia, hypertension, vascular inflammation, insulin resistance and diabetes, atherosclerosis, angiogenesis, coronary artery disease, myocardial infarction and heart failure. Methods: Gene expression of 29 microRNAs was compared between groups (39 GH, 68 PE, 33 IUGR and 20 normal pregnancies) and correlated with the severity of the disease with respect to clinical signs, delivery date and Doppler US parameters.