Jornal de Ensaios Clínicos
Acesso livre

Abstrato

Human Saliva: It's Utility as a Biological Matrix in the Quantification of Pharmacological Active Agents (Drugs)

Chika J Mba

Quantification of pharmacological active agents (drugs) in biological fluids is very often performed to evaluate patient adherence and track the effectiveness of the dose that was administered. Though mostly used in diagnostic and forensic/toxicology analyses, a number of reports have utilized saliva as an alternate matrix to whole blood, plasma, serum and urine in drug concentrations determinations. The objective of the study was to present summary of numerous studies on saliva as a biological matrix.

Prediction of Saliva-Plasma transfer ratios by mathematical models combined with pharmacokinetic, and physiological data supporting interpretation of saliva drug concentrations, have greatly enhanced the value of saliva as a biological matrix for drug concentrations quantification.