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Huntington’s Disease: Current Status and Prospects

Ping An and Xiaoli Sun

Huntington’s disease (HD) is a hereditary neurodegenerative disorder caused by the mutant HTT gene. Its monogenetic nature offers unique advantages in HD basic and translational research. Recently, major advances in the revealing of its mechanisms have led to promising therapeutic strategies, which provide novel insights into other neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and ataxias. In this review, we will briefly discuss recent important progresses in HD research.