Jornal de Glicobiologia

Jornal de Glicobiologia
Acesso livre

ISSN: 2168-958X

Abstrato

Immune Response Modulation by Tumor-Secreted Glycosphingolipids

Ricardo D Lardone, Ingrid Cely, Peter A Sieling, and Delphine J Lee

Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) are now recognized as having critical effects on cellular physiology, including proliferation, differentiation, viral transformation and ontogenesis. In addition, a vast majority of human cancers have modified GSL composition compared to parental normal cells. These modifications may contribute to both tumor survival and exert striking effects on anti-tumor immunity. In this review, we discuss mechanisms of immune modulation by tumor-secreted GSL.

Isenção de responsabilidade: Este resumo foi traduzido com recurso a ferramentas de inteligência artificial e ainda não foi revisto ou verificado.
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