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Immune Thrombocytopenic Purpura Following Acute Lymphoblastic Leukemia in Remission

Olaniyi John A, Ogundeji Peter S and Ogbaro Daniel D

This is a case report of a 19 year old male undergraduate with a background diagnosis of polycystic kidney and hypertension. Two years thereafter, he was diagnosed to have ALL L1 morphology which responded to induction chemotherapy using Vincristine and Prednisolone (V+P). He later proceeded to India where the same diagnosis was confirmed and molecular study pointed to standard risks ALL. Following successful Induction Remission and Consolidated therapy, he was sent to us to follow up his maintenance therapy. Patient defaulted severally. He represented with severe thrombocytopenia and thrombocytopenic bleeding with blood film and marrow being devoid of blasts but rather marrow showed numerous smooth, non-budding, cytoplasmic basophilic megakaryocytes in keeping with ITP. He responded rapidly to steroid therapy. Patient remains stable as at now after 3 months of steroid therapy. ITP following ALL in remission is an uncommon occurrence, hence this report.