Jornal de Patologia Médica e Cirúrgica
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Infiltrating Syringomatous Adenoma of the Nipple: A Case Report

Lance Buckthought, Jamish Gandhi, Aleksandra Popadich, Rachel Barber

We describe a case of a 46-year-old woman who was treated initially for a presumed non-lactational breast abscess.
As symptoms did not subside with conservative management a major duct excision was conducted and histology revealed an infiltrating syringomatous adenoma.
She underwent further surgery to achieve clear margins and the tumour is the largest reported to date.
These are benign, infiltrating lesions and are rare with less than 40 cases reported in the literature.
Patients usually present with a retro-areolar mass and adjacent skin and nipple changes. Radiologically they are difficult to differentiate from breast cancer and diagnosis is largely confirmed through histologic and immunohistochemical analysis.
Treatment is with local excision to achieve clear margins as recurrence rates are high with residual tumour.