ISSN: 2329-9495
Julius Samson
Many chronic conditions, as diabetes (DM) and cardiovascular Diseases, suffer Major Adverse Cardiac Events (MACE): i myocarditis, congestive heart failure (CHF), Ventricular Tachycardia (VT), Ventricular Fibrillation (VF), Acute Coronary Syndromes [ACSs], and Sudden Cardiac Death (SCD) Acute infections, like COVID-19,also involve oxidative stress, leading to increased Sympathetic tone (S) and decreased Parasympathetic tone (P), increasing Sympathovagal Balance (SB) and MACE.The antioxidant (r)alpha lipoic acid(ALA) improves SB. The anti-anginal Ranolazine (RAN), also an antioxidant,.is an anti-arrhythmic. Our studies of their effects on MACE, in DM, and non-DM patients with CHF, ventricular arrhythmias and SCD are reviewed herein, as our findings may apply to acute diseases, such as COVID-19