Jornal de Nanomedicina e Descoberta Bioterapêutica
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Magnetically Triggered Drug Release from Liposome Embedded Gel

Jae-Ho Lee, Robert Ivkov and Robert Blumenthal

Triggering drug release in tumor or disease sites at specific times can be one approach to treat diseases efficiently by limiting side effects from high systemic or off-target exposure. In this study we investigated triggered drug release of a liposome gel by magnetic heating from Iron Oxide Magnetic Nanoparticles (IMN). The liposome gel was prepared by self-assembly of drug encapsulated liposomes, IMN, and hydrophobically-modified chitosan (hmC) solution. The triggering release of the liposome gel was investigated in the Alternating Magnetic Field (AMF). In addition, AMF effect in cell toxicity of the doxorubicin liposome was evaluated. Drug release from the liposome gel via AMF demonstrated triggered release and enhanced cancer cell killing effect.