Jornal de Toxicologia Clínica
Acesso livre

Abstrato

Metabolic Diseases and Oxidative Stress

Radha Saraswathy*, Aswathi Rajagopalan

Metabolic syndrome is a public health problem that has been rapidly increasing from the last century. This condition
is a cluster of pathophysiological malformation which includes cardiovascular disease, obesity, diabetes, hypertension,
neurodegenerative diseases, and insulin resistance and obesity is a major modifiable causing factor for metabolic
disease. The development and pathogenesis of metabolic syndromes is an imbalance between reactive oxygen species
(ROS) and free radicals formation. Several clinical studies have reported that they can be triggered by the reactive
oxygen species, genetic, environmental, lifestyle alterations, such as lack of physical inactivity, unhealthy dietary
habits, alcohol consumption. Oxygen is essential for the living system at the same time oxygen may also be dangerous
to the same biological system. ROS can injure cellular macromolecules leading to apoptosis and necrosis. ROS plays a
vital role in physiological processes and a favorable role in the immune system. Low levels of ROS produced by
mitochondrial respiration may continue oxidative damage to several metabolic syndromes. This review discusses the
effect of oxidative stress on metabolic disease