Medicina Interna: Acesso Aberto
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Non-Ulcer Dyspepsia: A Review of the Pathophysiology, Evaluation, and Current Management Strategies

Charles W. Randall, Jonathan Zaga-Galante and Adriana Vergara-Suarez

Non-Ulcer-Dyspepsia (NUD) is defined by The Rome III criteria as a chronic or recurrent epigastric pain within the last 3 months and an onset of symptoms at least 6 months prior to presentation. This disease has become a very common and costly condition, for the patient himself, and for the physician to diagnose it. It is not only the complexity of the pathophysiology that makes this disease a challenging diagnosis for the physician, it also the lack of testing strategies to approach a patient with this problem. In this review we will summarize the current universe of information of NUD, we will also cover the pathophysiology and the current guidelines for the evaluation and management, so the physician has a better sense of how to engage this common and difficult type of patients.