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Ocular Surface Changes with Sofosbuvir in Egyptian Patients with Hepatitis C Virus Infection

Marsida Krasniqi and Ahmed Abdel Kader Farrag

Background: To detect any ocular surface changes with Sofosbuvir in Egyption patients with hepatitis C virus.

Design: Continuous audit over 3 months for patients enrolled for Sofosbuvir therapy.

Participants: A total of 100 Egyptian Chronic hepatitis C patients enrolled for Sofosbuvir therapy, Egypt, from January 2018 to March 2018.

Methods: Ocular history.

Ocular examination including: Visual acuity measurement. Slit-lamp bio microscopy of the ocular surface.

Schirmer’s test: To exclude dry eye, Break up time test, Conjunctival impression cytology.

Main outcome measures: After the treatment, BUT and Schirmer test declined from 13.08 second and 14.47 mm to 6.4 second and 7.98 mm respectively. Regarding impression cytology, the mean N/C ratio decreased from 0.66 to 0.57 while squamous metablasia and keratinization was found in 16% of patients post treatment. It was also found that 44% were complaining of dry eye symptoms after the treatment.

Conclusion: Our study detected ocular surface changes after three months of sofosbuvir treatment for HCV.