Jornal de Oftalmologia Clínica e Experimental
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Prophylactic Effect of Miosis against Early Intraocular Pressure Elevation after V4c Phakic Intraocular Lens Implantation

Zongli Hu, Chunlin Chen, Min Sun, Rongdi Yuan and Jian Ye

Purpose: To confirm the prophylactic effect of miosis against intraocular pressure (IOP) early after V4c phakic
intraocular lens (ICL) implantation.
Design: Interventional case series.
Participants: Forty-six myopia patients scheduled for ICL implantation.
Methods: This study was performed in 2 stages. In stage 1 (58 eyes of 29 patients), miosis was conducted
immediately postoperative in left eyes, whereas right eyes remained untreated. IOP was compared between right
and left eyes at postoperative hours 1, 2, 6, 12 and 24. In stage 2 (34 eyes of 17 patients), miosis was first
conducted immediately postoperative in left eyes, and IOP, anterior chamber depth (ACD), angle-opening distance
(AOD) and trabecular-iris angle (TIA) were measured in both eyes (right/left eye pupil diameter (PD)=7 ± 0.5/3 ± 0.5
mm). Second, miosis (right) or mydriasis (left) was conducted and these indicators were observed when PD
decreased to 3 ± 0.5 mm (right) or increased to 7 ± 0.5 mm (left).
Results: In stage 1, IOP was significantly higher in right eyes at postoperative hours 1, 2, 6 and 12 (p<0.01). The
prevalence of ocular hypertension was significantly different (Purpose to confirm the prophylactic effect of miosis
against intraocular pressure (IOP) early after V4c phakic intraocular lens (ICL) implantation.
Conclusion: Miosis lowered postoperative IOP early after V4c ICL implantation, possibly due to a more open
angle.