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Prostatic Ductal Adenocarcinoma: Case Report and Literature Review

Sheng-Lung Hsu, Chien-Feng Li, Kun-Hung Shen, Chiu-Lan Chen and Mei-Li Chen

Prostatic Duct Adenocarcinoma (PDA), not a unique disease but with nearly 5% of the prostate carcinoma, clinically deviated from common Prostatic Acinar Adenocarcinoma (PAA) in recent years and was deemed the exact existence even with its long-standing origin debates. Addedly, it was usually more aggressive than PAA in most studies. As for our daily urologic practice, the 2 PDA cases (with obstruction symptoms; with gross hematuria) progressed to imaging-indicated bone metastases and were probably historically in the large primary periurethral prostatic ducts or the peripheral prostatic ducts and extending exophytically into the urethra and most commonly in and around the verumontanum before retrospective chart reviews. Convincingly, though the early diagnosis and aggressive treatment failed, long term follow-up for disease outcomes stayed serious. Indeed, the rate of the gene fusion in the pure PDA was significantly lower genetically and biologically than that in the PAA and will be likewise examined.